Johnny Quest [TV]

Doug Wildey created this 1964 animated Adventure Series, the first produced by Hanna-Barbera and the first to use realistically drawn human characters in Science Fiction or adventure settings. The series aired in prime time on ABC.
The young hero Jonny Quest (voiced by later Animal House star Tim Matheson) traveled the world with his father, Dr. Benton Quest; Roger “Race” Bannon, a friend and bodyguard of Dr. Quest; Hadji, Jonny’s adopted brother from India, and Bandit, the family dog. (The first episode establishes that Jonny’s mother, Rachel, died before the series began.)
A second Jonny Quest series was syndicated in 1986-87, with two new characters: Jessie Bradshaw, whose father was a colleague of Dr. Quest, and Hard Rock, a man made of living stone. This series culminated in two made-for-TV movies – Jonny’s Golden Quest and Jonny Quest Versus The Cyber Insects – which introduced Race Bannon’s daughter, Jessie (not the same character as Jessie Bradshaw).
Cartoon Network made some changes to the format when it debuted Jonny Quest The Real Adventures in 1996. New characters included Race’s daughter Jessie (not the same as the non-canon Jessie above), the recurring villains Jeremiah Surd and Ezekiel Rage, and the twin daughters of Dr. Zin (who, of course, was from the original series). Also, the characters had access to Questworld, a virtual reality realm represented in most episodes by 3-D computer animation. According to this Wikipedia article, development began in 1992, but the series went through three production teams over the next four years.
A Live-Action Adaptation of Jonny Quest was announced in August 2007, with recent news placing Zac Efron as Jonny and The Rock as Race Bannon.