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Fullmetal Alchemist: Brotherhood, commonly referred to as FMAB is the second adaptation of the hit manga series Fullmetal Alchemist by Hiromu Arakawa. In 2003, shortly after the manga began its run, the first adaptation titled Fullmetal Alchemist was made.

The series follows Dr. Kenzo Tenma as he pursues a young psychopath/sociopath named Johan, whose life Tenma had once saved.

Ikebukuro, Tokyo. Mikado Ryugamine is a young man who yearns for the city like no other.

The story follows Kaizaki Arata, a 27-year-old jobless man, who fails at every job interview he had after quitting his last company. His life changes after he met Yoake Ryou of the ReLife Research Institute, who offered him a drug that can change his appearance to 17-years-old and to become a subject in an experiment for one year.