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Fullmetal Alchemist: Brotherhood, commonly referred to as FMAB is the second adaptation of the hit manga series Fullmetal Alchemist by Hiromu Arakawa. In 2003, shortly after the manga began its run, the first adaptation titled Fullmetal Alchemist was made.

Set in a gothic fantasy world, this is the story of Teito Klein, an orphaned slave who became the top military academy student. However, an unexpected turn of events left him pursued by the forces of the Barsburg Empire.

A fugitive alchemist with mysterious abilities leads the Elric brothers to a distant valley of slums inhabited by the Milos, a proud people struggling against bureaucratic exploitation. Ed and Al quickly find themselves in the middle of a rising rebellion, as the exiled Milos lash out against their oppressors.

The brothers Elric will consider the answers that are left once the Philosopher's Stone has guided their saga to and end. True sacrifice, the deep love of family, the cruel truths of life and death.

In the beginning of the 21st century, a world war breaks out over interplanetary travel tech. The environment is pretty much destroyed so mankind leaves Earth and starts Star Calendar 00.

The story revolves around Rin Okumura, a teenager possessing abnormal strength and endurance who, along with his younger twin brother Yukio, was raised by Father Shiro Fujimoto. Soon after Yukio departs to study at the prestigious True Cross Academy, Rin learns that he is the son of Satan, the strongest of all demons.