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They say that you'll never know what a person's real character is until you've started living with him/her/ them under one roof. Well, it definitely is true in the case of a 16 year old female protagonist, Tohru Honda from the series, Fruits Basket.

The curse of an evil witch turns a plain young hat-maker, Sophie, into an old woman. Sophie runs away to confront the witch and become young again when she rescues a trapped animated scarecrow.

Edward Elric makes a fatal mistake that drags his brother and his own body into an abyss, and they must seek the philosopher's stone to return their bodies to normal. They learn more and more about alchemy along the way during their adventures.

Komatsu Nana moves to Tokyo, following after her boyfriend Shouji to gain a life she has always dreamed of. The anime is about two girls named Nana, who are very different.

Bulma is a girl in search of the mystical dragonballs that when brought together grant any wish. In her search she bumps into the owner of one of these balls, a strange boy named Goku.

This story is centered around a girl named Kuronuma Sawako who is nicknamed Sadako (ghost girl from “The Ring”) by her classmates because of her scary face and demeanor. She greatly admires Kazehaya-kun from afar, he is “100% refreshing” and is able to draw in people with his personality.

Goku is back with his new son, Gohan, but just when things are getting settled down, the adventures continue. Whether he is facing enemies such as Frieza, Cell, or Buu, Goku is proven to be an elite of his own and discovers his race, Saiyan and is able to reach Super Saiyan 3 form.

Ruthless and an unstoppable mercenary, Train Heartnet completes his jobs with deadly accuracy. Donning the nickname “Black Cat”, he works for a powerful underground secret organization called Chronos.

During the late 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis, are looking for missing bottles of the immortality elixir.

Cross Academy is different from any other school. It has a Day Class and a Night Class, with different uniforms and no interaction between these two classes.

Chihiro and her family are on their way to their new house in the suburbs when her father decides to take a shortcut along a lonely-looking dirt road. After getting out of the car and walking along a path for a while, they discover an open-air restaurant filled with food but with no workers or customers present.

Haruhi Fujioka is searching for nothing more than a quiet place to study in the most elite high school academy in all of Japan when she stumbles across the mysterious third music room. Inside she encounters six beautiful men, the members of the host club.

As the Cowboy Bebop crew travels the stars, they learn of the largest bounty yet, a huge 300 million oolongs. Apparently, someone is wielding a hugely powerful chemical weapon, and of course the authorities are at a loss to stop it.

Gurren Lagann takes place in a fictional future where Earth is ruled by the Spiral King, Lordgenome, who forces mankind to live in isolated subterranean villages. These villages have no contact with the surface world or other villages, and are under constant threat of earthquakes.

The story begins when high school student Kazuki Muto is killed one night saving a mysterious girl from a monster, only to wake up in his school dorm, believing it to have been a dream. However, he soon finds out that dream wasn't a dream at all when a giant serpentine monster attacks him and his sister.

Train Heartnet, also known as "Black Cat," was an infamous assassin for a secret organization called Chronos..

Equipped with technologically advanced weaponry and specialized elite troops, private military organization Mithril covertly protects the Earth’s peace and order from the threat of destruction and terrorism. The backbone of Mithril’s operations rely on the Whispered, a group of exemplary and intelligent individuals, responsible for the invention and production of powerful machinery.

Kurosaki Ichigo is not your average, everyday 15-year-old high school student. He has from as far he can remember always had the ability to see ghosts and spirits.

When a great demon fox attacked Hidden Leaf Village, a powerful man known as the 4th Hokage had sealed the demon inside a newborn named Naruto, who then grew up detested by his fellow Leaf villagers. As a child, Naruto is isolated from the Konoha community, who regards him as if he was the Nine-Tails.

Kagome Higurashi, a normal 15-year-old girl, falls down a dry well--and finds herself in the feudal past, 50 years after her ancestress Kikyo imprisoned the half-human/half-demon Inu-Yasha. As the reincarnation of Kikyo, Kagome possesses a magic jewel that greatly increases the power of demons.

Amu Hinamori is a student at Seiyo Elementary, where she has a reputation for being "cool and spicy"; however, her real personality is that of an extremely shy and easily intimidated girl. One night Amu makes a wish that she would have the courage to be reborn as her "would-be" self.