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After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy infooo carries a heavy price.

Misaki Ayuzawa is the first female student council president at a once all boys school turned co-ed. She rules the school with strict discipline demeanor.

Kurosaki Ichigo is not your average, everyday 15-year-old high school student. He has from as far he can remember always had the ability to see ghosts and spirits.

In Karakura Town, there has been a sudden outbreak of unidentifiable spirits called "blanks" (vacant souls) while in the skies of Soul Society, the real world has been reflected. A mysterious female shinigami called Senna has appeared before Ichigo along with a man named Ganryu, leading a group called the "Dark Ones".

Fullmetal Alchemist: Brotherhood, commonly referred to as FMAB is the second adaptation of the hit manga series Fullmetal Alchemist by Hiromu Arakawa. In 2003, shortly after the manga began its run, the first adaptation titled Fullmetal Alchemist was made.