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Emma, Norman, Ray, and many other "siblings" live at an isolated orphanage cut off from the outside world. They live a charmed life surrounded by friends and watched over by Mama, their caretaker, until they leave the house for a foster family by the age of twelve.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.