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Rintaro Okabe is a self-proclaimed "mad scientist" who believes that an international scientific organization named SERN is conspiring to reshape the world according to its own interests. He and his friend Itaru Hashida inadvertently create a gadget able to send messages to the past.

One night, a strange object falls on the head of Nitta, a member of the yakuza. Inside the box is a strange young girl named Hina.

It's not your typical shonen. You might be wondering, what’s Gintoki’s end goal here?

During the late 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis, are looking for missing bottles of the immortality elixir.