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The world is beginning to get back on it's feet and rebuild after the destruction that lied in Sephiroth's wake. Not all is going well, however, as a new disease known as Geostigma threatens the world.

A planet is overrun by a mysterious group of creatures that infect and destroy all life on Earth. Only the determination of a single woman to find a cure will prevent the world from slowly being eaten away.

10-year-old Satoshi, after finding a Pikachu messing with the wiring in his house, is on a journey to become the greatest Pokemon Master and to beat out his rival, Shigeru. Along the way, he meets with many other Pokemon trainers and advisors, including water-based trainer (and gym leader) Kasumi, ground- and rock-based trainer (and gym leader) Takeshi, and others.

Ash is a young boy who has always dreamed of becoming a Pokemon trainer. At age 11 he is gifted his first Pokemon, Pikachu, from Professor Oak.